Proud to share a research milestone from Akeso Eyecare, led by Mojtaba Moghaddasi, Optical Scientist at Akeso. In collaboration with researchers from Beijing Institute of Technology, Harbin Engineering University, and partner universities, this work has been published in Laser & Photonics Reviews, one of the world’s leading journals in optics and photonics. The study presents a compact, large–field-of-view metalens-based polarization imaging system with strong potential for earlier disease detection, especially in gastrointestinal cancers.
Dec 17, 2025
Recently, AKESO Eyecare, together with research teams from Beijing Institute of Technology, Harbin Engineering University, and several other universities, published groundbreaking research in the internationally renowned journal Laser & Photonics Reviews.
The team led by Mojtaba Moghaddasi (Optical Scientist at Akeso), successfully developed a compact, large–field-of-view 3×3 Mueller-matrix polarization imaging system based on metalenses. This innovative technology provides a new solution for the early diagnosis of diseases—particularly gastrointestinal cancers—and represents a significant advancement in the field of nano-optical medical imaging.
Metalenses are planar optical elements based on metasurfaces. By using arrays of subwavelength nanostructures, they precisely manipulate phase, amplitude, and polarization of light—enabling focusing, imaging, achromatism, polarization conversion, and more—effectively replacing traditional curved glass lenses.
Compared with conventional lenses, metalenses offer major advantages in five key dimensions:
Thanks to their compactness, multifunctionality, semiconductor-compatible manufacturing, and high optical efficiency, metalenses hold significant promise across consumer electronics, medical devices, autonomous driving, and other industries. As photolithography technologies and materials continue to advance, metalenses will further enhance optical system performance while reducing size, power consumption, and cost—accelerating the transition from laboratory to industrial applications.
The fabrication of metalenses critically depends on advanced photolithography. As the core technique for patterning subwavelength nanostructures, the resolution, throughput, and cost of photolithography directly determine the performance, scalability, and commercialization progress of metalenses.
With future advancements in lithography resolution and process optimization, metalenses will become increasingly widespread in imaging, sensing, displays, and communication technologies.
Driven by both industrialization demands and ongoing research innovation, Akeso plans to further explore advanced manufacturing pathways for metalenses by integrating its MetaRx lithography technology. This will provide core support for mass production and functional upgrades of high-performance optical devices.
MetaRx technology—with subwavelength-level fabrication accuracy (errors controlled within ±5 nm) and exceptional large-area uniformity—perfectly meets the manufacturing requirements of metalens nanostructures. Its hybrid lithography and step-and-repeat imprinting process enhances fabrication efficiency by over 80×, while ensuring structural consistency across metalenses designed for three polarization directions. This dramatically reduces the production cost of high-performance metalenses.
Leveraging MetaRx’s high-refractive-index material integration and high-precision, low-loss fabrication capabilities, the Akeso's research team will further explore the deep integration of metalenses with artificial intelligence.
The next generation of imaging systems will feature:
These innovations will offer more precise tools for early disease detection while also supporting cutting-edge fields such as nondestructive testing, biomedical imaging, and quantum optics. Akeso aims to continue driving innovation at the intersection of metasurface optics and medical imaging technologies.
To read the full journal/article - visit https://onlinelibrary.wiley.com/doi/10.1002/lpor.202501305
At the heart of this publication is the value of research itself: years of work at the intersection of optics, photonics, and medicine, focused on enabling earlier disease detection. Its acceptance in Laser & Photonics Reviews, one of the world’s leading journals in the field, underscores the study’s global relevance and future impact. We also wish to recognize the principal author, Mojtaba, whose leadership and close collaboration with AKESO and academic–industry partners were central to shaping a study that combines rigorous science with meaningful real-world medical outcomes.
Akeso Eyecare is a doctor-founded eye-technology company and CDMO focused on improving vision care. We design and build advanced solutions like AR displays for myopia prevention, eye tracking, extended reality devices, and digital vision health tools used in eye care and smart technology.
Our mission is to improve global vision health through smart innovation. By combining optical design, materials science, and AI, our R&D team supports partners from early research to custom design, manufacturing, and large-scale production, always guided by medical expertise, collaboration, sustainability, and patient-first thinking.
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